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J Clin Lab Anal
. 2020 Aug 25;e23535.
doi: 10.1002/jcla.23535. Online ahead of print.
Severe Coronavirus disease 2019 pneumonia patients showed signs of aggravated renal impairment
Menglu Gao 1 , Qianying Wang 1 , Jianhao Wei 1 , Zhaoqin Zhu 1 , Haicong Li 1
Affiliations
- PMID: 32840917
- DOI: 10.1002/jcla.23535
Abstract
Background: This objective of this study was to identify a sensitive indicator of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Methods: Samples were collected from 136 patients with Coronavirus disease 2019 (COVID-19) pneumonia admitted to the Shanghai public health clinical center (116 mild, 20 severe). The concentrations of serum urea, Uric Acid (UA), Creatinine (CREA), Erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hs-CRP), procalcitonin (PCT), and urine protein (Pro) have been tested in this study.
Results: Higher levels of urea (female 7.00 ? 3.31, male 8.87 ? 5.18) Pro (female7/7, male 12/13), hs-CRP (female 2/7, male 5/13) ESR (female 94.43 ? 33.26, male 67.85 ? 22.77) were found in severe patients compared with the mild (urea: female 3.71 ? 1.00, male 4.42 ? 1.14; Pro: female 3/46, male 12/70; hs-CRP: female 1/46, male 3/70; ESR: female 43.32 ? 33.24, male 21.64 ? 21.82). UA is lower in the severe group (female 146.90 ? 54.01, male 139.34 ? 66.95) than in mild group (female 251.99 ? 64.35, male 339.81 ? 71.32). CREA and PCT did not show a significant difference between mild and severe patients, but the difference among the five biological markers (urea, Pro, hs-CRP, ESR, and UA) between mild and severe patients we tested was small (P < .05).
Conclusion: Severe COVID-19 patients had higher levels of urea and Pro, while their UA levels were lower, reflecting poor kidney function in severe patients. However, higher levels of hs-CRP, ESR indicated that inflammatory responses were more active in severe patients.
Keywords: COVID-19; ESR; UA; creatinine; hs-CRP; procalcitonin; urea; urine protein.