Announcement

Collapse
No announcement yet.

J Infect Dis. Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • J Infect Dis. Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia


    J Infect Dis. 2020 Mar 30. pii: jiaa150. doi: 10.1093/infdis/jiaa150. [Epub ahead of print]
    Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia.


    Wang F1, Nie J1, Wang H1, Zhao Q1, Xiong Y2, Deng L2, Song S2, Ma Z2, Mo P2, Zhang Y2.

    Author information




    Abstract

    BACKGROUND:

    Since December 2019, novel coronavirus (SARS-CoV-2)-infected pneumonia (COVID-19) occurred in Wuhan, and rapidly spread throughout China. We aimed to clarify the characteristics and clinical significance of peripheral lymphocyte subset alteration in COVID-19.
    METHODS:

    The levels of peripheral lymphocyte subsets were measured by flow cytometry in 60 hospitalized COVID-19 patients before and after treatment, and their association with clinical characteristics and treatment efficacy was analyzed.
    RESULTS:

    Total lymphocytes, CD4+ T cells, CD8+ T cells, B cells and natural killer (NK) cells decreased in COVID-19 patients, and severe cases had a lower level than mild cases. The subsets showed a significant association with the inflammatory status in COVID-19, especially CD8+ T cells and CD4+/CD8+ ratio. After treatment, 37 patients (67%) reached clinical response, with an increase of CD8+ T cells and B cells. No significant change of any subset was detected in non-response cases. In multivariate analysis, post-treatment decrease of CD8+ T cells and B cells and increase of CD4+/CD8+ ratio were indicated as independent predictors for poor efficacy.
    CONCLUSIONS:

    Peripheral lymphocyte subset alteration was associated with the clinical characteristics and treatment efficacy of COVID-19. CD8+ T cells tended to be an independent predictor for COVID-19 severity and treatment efficacy.
    ? The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.



    KEYWORDS:

    COVID-19; lymphocyte subset; pneumonia


    PMID:32227123DOI:10.1093/infdis/jiaa150

Working...
X