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Curr Opin Virol . Journey of monocytes and macrophages upon influenza A virus infection

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  • Curr Opin Virol . Journey of monocytes and macrophages upon influenza A virus infection

    Curr Opin Virol


    . 2024 Apr 1:66:101409.
    doi: 10.1016/j.coviro.2024.101409. Online ahead of print. Journey of monocytes and macrophages upon influenza A virus infection

    Cecilia Ruscitti 1 , Coraline Radermecker 1 , Thomas Marichal 2



    AffiliationsAbstract

    Influenza A virus (IAV) infections pose a global health challenge that necessitates a comprehensive understanding of the host immune response to devise effective therapeutic interventions. As monocytes and macrophages play crucial roles in host defence, inflammation, and repair, this review explores the intricate journey of these cells during and after IAV infection. First, we highlight the dynamics and functions of lung-resident macrophage populations post-IAV. Second, we review the current knowledge of recruited monocytes and monocyte-derived cells, emphasising their roles in viral clearance, inflammation, immunomodulation, and tissue repair. Third, we shed light on the consequences of IAV-induced macrophage alterations on long-term lung immunity. We conclude by underscoring current knowledge gaps and exciting prospects for future research in unravelling the complexities of macrophage responses to respiratory viral infections.


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