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DOI: https://doi.org/10.22141/2312-413x.2.11.2016.77537
Unwanted Immunology
M.V. Supotnytskyi
Abstract
The paper considers the role of antigenic imprin?ting phenomena and antibody-dependent enhancement of infection in epidemic, infectious and postvaccinal processes. Based on published experimental data, it is shown that both phenomena are directly related to the laws of development and course of epide?mics, the pathogenesis of infectious diseases and safe use of vaccines. Their ignoring by researchers has led to failures in the design of vaccines against HIV/AIDS, dengue fever, influenza, malaria, hemorrhagic fever and encephalitis. These data show that, without taking into account the two phenomena, the further development of immunology and epidemiology in the direction of breakthrough discoveries in there areas of science are impossible.
Keywords
phenomenon of the original antigenic sin; anamnestic response; antigenic imprinting; immunoglobulin; antibody; swine flu; flu; vaccine; viral protein; phenomenon of antibody-dependent enhancement of infection; complement; cross-reactive antibodies
Full Text:
PDF (Русский)
Unwanted Immunology
M.V. Supotnytskyi
Abstract
The paper considers the role of antigenic imprin?ting phenomena and antibody-dependent enhancement of infection in epidemic, infectious and postvaccinal processes. Based on published experimental data, it is shown that both phenomena are directly related to the laws of development and course of epide?mics, the pathogenesis of infectious diseases and safe use of vaccines. Their ignoring by researchers has led to failures in the design of vaccines against HIV/AIDS, dengue fever, influenza, malaria, hemorrhagic fever and encephalitis. These data show that, without taking into account the two phenomena, the further development of immunology and epidemiology in the direction of breakthrough discoveries in there areas of science are impossible.
Keywords
phenomenon of the original antigenic sin; anamnestic response; antigenic imprinting; immunoglobulin; antibody; swine flu; flu; vaccine; viral protein; phenomenon of antibody-dependent enhancement of infection; complement; cross-reactive antibodies
Full Text:
PDF (Русский)