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Immunity to Influenza Infection in Humans

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  • Immunity to Influenza Infection in Humans


    Cold Spring Harb Perspect Med. 2019 Dec 23. pii: a038729. doi: 10.1101/cshperspect.a038729. [Epub ahead of print] Immunity to Influenza Infection in Humans.

    Topham DJ1, DeDiego ML2, Nogales A3, Sangster MY1, Sant A1.
    Author information

    1 David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA. 2 Centro Nacional de Biotecnolog?a, Consejo Superior de Investigaciones Cientificas, 28049 Madrid, Spain. 3 Instituto Nacional de Investigaci?n y Tecnologia Agraria y Ailmentaria, 28040 Madrid, Spain.

    Abstract

    This review discusses the human immune responses to influenza infection with some insights from studies using animal models, such as experimental infection of mice. Recent technological advances in the study of human immune responses have greatly added to our knowledge of the infection and immune responses, and therefore much of the focus is on recent studies that have moved the field forward. We consider the complexity of the adaptive response generated by many sequential encounters through infection and vaccination.
    Copyright ? 2019 Cold Spring Harbor Laboratory Press; all rights reserved.


    PMID: 31871226 DOI: 10.1101/cshperspect.a038729

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