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Exogenous Interleukin-33 Contributes to Protective Immunity via Cytotoxic T-Cell Priming against Mucosal Influenza Viral Infection

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  • Exogenous Interleukin-33 Contributes to Protective Immunity via Cytotoxic T-Cell Priming against Mucosal Influenza Viral Infection

    Viruses. 2019 Sep 10;11(9). pii: E840. doi: 10.3390/v11090840.
    Exogenous Interleukin-33 Contributes to Protective Immunity via Cytotoxic T-Cell Priming against Mucosal Influenza Viral Infection.

    Kim CW1, Yoo HJ2, Park JH3, Oh JE4, Lee HK5,6,7.
    Author information

    1 Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea. chaewon.kim@kaist.ac.kr. 2 Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea. yoohyejee@kaist.ac.kr. 3 Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea. janghyun.park@kaist.ac.kr. 4 Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Korea. Jieun.oh@kaist.ac.kr. 5 Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea. heungkyu.lee@kaist.ac.kr. 6 Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Korea. heungkyu.lee@kaist.ac.kr. 7 KAIST Institute for Health Science and Technology, KAIST, Daejeon 34141, Korea. heungkyu.lee@kaist.ac.kr.

    Abstract

    Influenza is an infectious respiratory illness caused by the influenza virus. Though vaccines against influenza exist, they have limited efficacy. To additionally develop effective treatments, there is a need to study the mechanisms of host defenses from influenza viral infections. To date, the mechanism by which interleukin (IL)-33 modulates the antiviral immune response post-influenza infection is unclear. In this study, we demonstrate that exogenous IL-33 enhanced antiviral protection against influenza virus infection. Exogenous IL-33 induced the recruitment of dendritic cells, increased the secretion of pro-inflammatory cytokine IL-12, and promoted cytotoxic T-cell responses in the local microenvironment. Thus, our findings suggest a role of exogenous IL-33 in the antiviral immune response against influenza infection.


    KEYWORDS:

    IL-33; antiviral immunity; influenza virus

    PMID: 31509992 DOI: 10.3390/v11090840
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