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CD4+ TSCMs in the Bone Marrow Assist in Maturation of Antibodies against Influenza in Mice

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  • CD4+ TSCMs in the Bone Marrow Assist in Maturation of Antibodies against Influenza in Mice

    Mediators Inflamm. 2019 Jan 10;2019:3231696. doi: 10.1155/2019/3231696. eCollection 2019.
    CD4+ TSCMs in the Bone Marrow Assist in Maturation of Antibodies against Influenza in Mice.

    Wu K1,2,3, Wang F1,2, Guo G2, Li Y2,3, Qiu LJ4, Li X2,3.
    Author information

    Abstract

    The bone marrow (BM) is not only a reservoir of hematopoietic stem cells but a repository of immunological memory cells. Further characterizing BM-resident memory T cells would be helpful to reveal the complicated relationship between the BM and immunological memory. In this study, we identified CD122high stem cell antigen-1 (Sca-1) high B cell lymphoma 2 (Bcl-2) high CD4+ stem cell-like memory T cells (TSCMs) as a distinct memory T cell subset, which preferentially reside in the BM, where they respond vigorously to blood-borne antigens. Interestingly, the natural CD4+ TSCMs homing to the BM colocalized with VCAM-1+ IL-15+ IL-7+ CXCL-12+ stromal cells. Furthermore, compared to spleen-resident CD4+ TSCMs, BM-resident TSCMs induced the production of high-affinity antibodies against influenza by B lymphocytes more efficiently. Taken together, these observations indicate that the BM provides an appropriate microenvironment for the survival of CD4+ TSCMs, which broadens our knowledge regarding the memory maintenance of antigen-specific CD4+ T lymphocytes.


    PMID: 30733641 PMCID: PMC6348795 DOI: 10.1155/2019/3231696
    Free PMC Article
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