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Original Antigenic Sin: How First Exposure Shapes Lifelong Anti-Influenza Virus Immune Responses

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  • Original Antigenic Sin: How First Exposure Shapes Lifelong Anti-Influenza Virus Immune Responses

    J Immunol. 2019 Jan 15;202(2):335-340. doi: 10.4049/jimmunol.1801149.
    Original Antigenic Sin: How First Exposure Shapes Lifelong Anti-Influenza Virus Immune Responses.

    Zhang A1, Stacey HD1, Mullarkey CE1, Miller MS2.
    Author information

    Abstract

    The term "original antigenic sin" (OAS) was first used in the 1960s to describe how one's first exposure to influenza virus shapes the outcome of subsequent exposures to antigenically related strains. In the decades that have passed, OAS-like responses have been shown to play an integral role in both protection from and susceptibility to infections. OAS may also have an important deterministic role in the differential efficacy of influenza vaccine responses observed for various age cohorts across seasons. In this article, we review how the understanding of OAS has progressed from its initial description and highlight important outstanding questions in need of further study.
    Copyright 2019 by The American Association of Immunologists, Inc.


    PMID: 30617114 DOI: 10.4049/jimmunol.1801149
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