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J Infect Dis. 2018 Dec 9. doi: 10.1093/infdis/jiy700. [Epub ahead of print]
Obesity-induced changes in T cell metabolism are associated with impaired memory T cell response to influenza and are not reversed with weight loss.
Jennifer R1, Green WD1, Alwarawrah Y2, Nichols AG2, Eisner W2, Danzaki K2, MacIver NJ2, Beck MA1.
Author information
Abstract
Background:
Obesity is an independent risk factor for increased influenza mortality and is associated with impaired memory T cell response, resulting in increased risk of infection. In this study, we investigated if weight loss would restore memory T cell response to influenza.
Methods:
Male C57BL/6J mice were fed either low-fat or high-fat diet to induce obesity. Once obesity was established, all mice received primary infection with influenza X-31. Following a recovery period, we switched half of the obese group to a low-fat diet to induce weight loss. Fifteen weeks after diet switch, all mice were given a secondary infection with influenza PR8, and memory T cell function and T cell metabolism were measured.
Results:
Following secondary influenza infection, memory T cell subsets in the lungs of obese mice were decreased compared to lean mice. At the same time, T cells from obese mice were found to have altered cellular metabolism, largely characterized by an increase in oxygen consumption. Neither impaired memory T cell response nor altered T cell metabolism was reversed with weight loss.
Conclusion:
Obesity-associated changes in T cell metabolism are associated with impaired T cell response to influenza, and are not reversed with weight loss.
PMID: 30535161 DOI: 10.1093/infdis/jiy700
Obesity-induced changes in T cell metabolism are associated with impaired memory T cell response to influenza and are not reversed with weight loss.
Jennifer R1, Green WD1, Alwarawrah Y2, Nichols AG2, Eisner W2, Danzaki K2, MacIver NJ2, Beck MA1.
Author information
Abstract
Background:
Obesity is an independent risk factor for increased influenza mortality and is associated with impaired memory T cell response, resulting in increased risk of infection. In this study, we investigated if weight loss would restore memory T cell response to influenza.
Methods:
Male C57BL/6J mice were fed either low-fat or high-fat diet to induce obesity. Once obesity was established, all mice received primary infection with influenza X-31. Following a recovery period, we switched half of the obese group to a low-fat diet to induce weight loss. Fifteen weeks after diet switch, all mice were given a secondary infection with influenza PR8, and memory T cell function and T cell metabolism were measured.
Results:
Following secondary influenza infection, memory T cell subsets in the lungs of obese mice were decreased compared to lean mice. At the same time, T cells from obese mice were found to have altered cellular metabolism, largely characterized by an increase in oxygen consumption. Neither impaired memory T cell response nor altered T cell metabolism was reversed with weight loss.
Conclusion:
Obesity-associated changes in T cell metabolism are associated with impaired T cell response to influenza, and are not reversed with weight loss.
PMID: 30535161 DOI: 10.1093/infdis/jiy700