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Biomed J. 2018 Aug;41(4):218-233. doi: 10.1016/j.bj.2018.08.004. Epub 2018 Sep 10.
The role of respiratory epithelium in host defence against influenza virus infection.
Denney L1, Ho LP2.
Author information
Abstract
The respiratory epithelium is the major interface between the environment and the host. Sophisticated barrier, sensing, anti-microbial and immune regulatory mechanisms have evolved to help maintain homeostasis and to defend the lung against foreign substances and pathogens. During influenza virus infection, these specialised structural cells and populations of resident immune cells come together to mount the first response to the virus, one which would play a significant role in the immediate and long term outcome of the infection. In this review, we focus on the immune defence machinery of the respiratory epithelium and briefly explore how it repairs and regenerates after infection.
KEYWORDS:
Airway epithelium; Defence; Influenza; Injury and repair; Sensing
PMID: 30348265 DOI: 10.1016/j.bj.2018.08.004
Free full text
The role of respiratory epithelium in host defence against influenza virus infection.
Denney L1, Ho LP2.
Author information
Abstract
The respiratory epithelium is the major interface between the environment and the host. Sophisticated barrier, sensing, anti-microbial and immune regulatory mechanisms have evolved to help maintain homeostasis and to defend the lung against foreign substances and pathogens. During influenza virus infection, these specialised structural cells and populations of resident immune cells come together to mount the first response to the virus, one which would play a significant role in the immediate and long term outcome of the infection. In this review, we focus on the immune defence machinery of the respiratory epithelium and briefly explore how it repairs and regenerates after infection.
KEYWORDS:
Airway epithelium; Defence; Influenza; Injury and repair; Sensing
PMID: 30348265 DOI: 10.1016/j.bj.2018.08.004
Free full text