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Reprogramming human T cell function and specificity with non-viral genome targeting
Reprogramming human T cell function and specificity with non-viral genome targeting
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The resulting TCR-engineered T cells specifically recognized tumour antigens and mounted productive anti-tumour cell responses in vitro and in vivo.,Together, these studies provide preclinical evidence that non-viral genome targeting can enable rapid and flexible experimental manipulation and therapeutic engineering of primary human immune cells.
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