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Nat Immunol. 2017 Sep 11. doi: 10.1038/ni.3837. [Epub ahead of print]
Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection.
Botta D1, Fuller MJ2, Marquez-Lago TT3,4, Bachus H2, Bradley JE2, Weinmann AS1, Zajac AJ1, Randall TD2, Lund FE1, Le?n B1, Ballesteros-Tato A2.
Author information
Abstract
Interleukin 2 (IL-2) promotes Foxp3+ regulatory T (Treg) cell responses, but inhibits T follicular helper (TFH) cell development. However, it is not clear how IL-2 affects T follicular regulatory (TFR) cells, a cell type with properties of both Treg and TFH cells. Using an influenza infection model, we found that high IL-2 concentrations at the peak of the infection prevented TFR cell development by a Blimp-1-dependent mechanism. However, once the immune response resolved, some Treg cells downregulated CD25, upregulated Bcl-6 and differentiated into TFR cells, which then migrated into the B cell follicles to prevent the expansion of self-reactive B cell clones. Thus, unlike its effects on conventional Treg cells, IL-2 inhibits TFR cell responses.
PMID: 28892471 DOI: 10.1038/ni.3837
Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection.
Botta D1, Fuller MJ2, Marquez-Lago TT3,4, Bachus H2, Bradley JE2, Weinmann AS1, Zajac AJ1, Randall TD2, Lund FE1, Le?n B1, Ballesteros-Tato A2.
Author information
Abstract
Interleukin 2 (IL-2) promotes Foxp3+ regulatory T (Treg) cell responses, but inhibits T follicular helper (TFH) cell development. However, it is not clear how IL-2 affects T follicular regulatory (TFR) cells, a cell type with properties of both Treg and TFH cells. Using an influenza infection model, we found that high IL-2 concentrations at the peak of the infection prevented TFR cell development by a Blimp-1-dependent mechanism. However, once the immune response resolved, some Treg cells downregulated CD25, upregulated Bcl-6 and differentiated into TFR cells, which then migrated into the B cell follicles to prevent the expansion of self-reactive B cell clones. Thus, unlike its effects on conventional Treg cells, IL-2 inhibits TFR cell responses.
PMID: 28892471 DOI: 10.1038/ni.3837