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DNA Cell Biol. 2017 Jun 8. doi: 10.1089/dna.2017.3791. [Epub ahead of print]
ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane (IFITM) Antiviral Activity.
Li S1, Fu B2,3, Wang L1, Dorf ME2.
Author information
Abstract
The zinc metalloprotease ZMPSTE24 is a constitutively and ubiquitously expressed host restriction factor that is responsible for limiting infection by a broad spectrum of enveloped viruses, including influenza A, vesicular stomatitis, zika, ebola, Sindbis, cowpox, and vaccinia viruses, but not murine leukemia or adenovirus. Antiviral function is independent of ZMPSTE24 enzymatic activity. Protein interaction and genetic complementation studies indicate that ZMPSTE24 is a component of a common antiviral pathway that is associated with interferon-induced transmembrane proteins. In vivo studies with zmpste24-deficient mice demonstrate the importance of ZMPSTE24 for antiviral defense.
KEYWORDS:
IFITM3 proteome; endosome; enveloped viruses; influenza; interferon; viral entry
PMID: 28594571 DOI: 10.1089/dna.2017.3791
ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane (IFITM) Antiviral Activity.
Li S1, Fu B2,3, Wang L1, Dorf ME2.
Author information
Abstract
The zinc metalloprotease ZMPSTE24 is a constitutively and ubiquitously expressed host restriction factor that is responsible for limiting infection by a broad spectrum of enveloped viruses, including influenza A, vesicular stomatitis, zika, ebola, Sindbis, cowpox, and vaccinia viruses, but not murine leukemia or adenovirus. Antiviral function is independent of ZMPSTE24 enzymatic activity. Protein interaction and genetic complementation studies indicate that ZMPSTE24 is a component of a common antiviral pathway that is associated with interferon-induced transmembrane proteins. In vivo studies with zmpste24-deficient mice demonstrate the importance of ZMPSTE24 for antiviral defense.
KEYWORDS:
IFITM3 proteome; endosome; enveloped viruses; influenza; interferon; viral entry
PMID: 28594571 DOI: 10.1089/dna.2017.3791