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Virol Sin. 2017 Feb 23. doi: 10.1007/s12250-016-3918-y. [Epub ahead of print]
Avian influenza virus directly infects human natural killer cells and inhibits cell activity.
Mao H1,2,3, Liu Y4, Sia SF5, Peiris JS5, Lau YL6,4,7, Tu W8.
Author information
Abstract
Natural killer (NK) cell is a key component of innate immunity and plays an important role in host defense against virus infection by directly destroying infected cells. Influenza is a respiratory disease transmitted in the early phase of virus infection. Evasion of host innate immunity including NK cells is critical for the virus to expand and establish a successful acute infection. Previously, we showed that human influenza H1N1 virus infects NK cells and induces cell apoptosis, as well as inhibits NK cell activity. In this study, we further demonstrated that avian influenza virus also directly targeted NK cells as an immunoevasion strategy. The avian virus infected human NK cells and induced cell apoptosis. In addition, avian influenza virion and HA protein inhibited NK cell cytotoxicity. This novel strategy has obvious advantages for avian influenza virus, allowing the virus sufficient time to expand and subsequent spread before the onset of the specific immune response. Our findings provide an important clue for the immunopathogenesis of avian influenza, and also suggest that direct targeting NK cells may be a common strategy used by both human and avian influenza viruses to evade NK cell immunity.
KEYWORDS:
avian influenza virus (AIV); cytotoxicity; direction infection; immunoevasion; inhibition; natural killer (NK) cell
PMID: 28255852 DOI: 10.1007/s12250-016-3918-y
[PubMed - as supplied by publisher]
Avian influenza virus directly infects human natural killer cells and inhibits cell activity.
Mao H1,2,3, Liu Y4, Sia SF5, Peiris JS5, Lau YL6,4,7, Tu W8.
Author information
Abstract
Natural killer (NK) cell is a key component of innate immunity and plays an important role in host defense against virus infection by directly destroying infected cells. Influenza is a respiratory disease transmitted in the early phase of virus infection. Evasion of host innate immunity including NK cells is critical for the virus to expand and establish a successful acute infection. Previously, we showed that human influenza H1N1 virus infects NK cells and induces cell apoptosis, as well as inhibits NK cell activity. In this study, we further demonstrated that avian influenza virus also directly targeted NK cells as an immunoevasion strategy. The avian virus infected human NK cells and induced cell apoptosis. In addition, avian influenza virion and HA protein inhibited NK cell cytotoxicity. This novel strategy has obvious advantages for avian influenza virus, allowing the virus sufficient time to expand and subsequent spread before the onset of the specific immune response. Our findings provide an important clue for the immunopathogenesis of avian influenza, and also suggest that direct targeting NK cells may be a common strategy used by both human and avian influenza viruses to evade NK cell immunity.
KEYWORDS:
avian influenza virus (AIV); cytotoxicity; direction infection; immunoevasion; inhibition; natural killer (NK) cell
PMID: 28255852 DOI: 10.1007/s12250-016-3918-y
[PubMed - as supplied by publisher]