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Inflamm Res. 2016 Oct 15. [Epub ahead of print]
The inflammatory response triggered by Influenza virus: a two edged sword.
Tavares LP1, Teixeira MM1, Garcia CC2,3.
Author information
Abstract
Influenza A virus (IAV) is a relevant respiratory tract pathogen leading to a great number of deaths and hospitalizations worldwide. Secondary bacterial infections are a very common cause of IAV associated morbidity and mortality. The robust inflammatory response that follows infection is important for the control of virus proliferation but is also associated with lung damage, morbidity and death. The role of the different components of immune response underlying protection or disease during IAV infection is not completely elucidated. Overall, in the context of IAV infection, inflammation is a 'double edge sword' necessary to control infection but causing disease. Therefore, a growing number of studies suggest that immunomodulatory strategies may improve disease outcome without affecting the ability of the host to deal with infection. This review summarizes recent aspects of the inflammatory responses triggered by IAV that are preferentially involved in causing severe pulmonary disease and the anti-inflammatory strategies that have been suggested to treat influenza induced immunopathology.
KEYWORDS:
Immunopathology; Inflammation; Influenza; Secondary infection
PMID: 27744631 DOI: 10.1007/s00011-016-0996-0
[PubMed - as supplied by publisher]
The inflammatory response triggered by Influenza virus: a two edged sword.
Tavares LP1, Teixeira MM1, Garcia CC2,3.
Author information
Abstract
Influenza A virus (IAV) is a relevant respiratory tract pathogen leading to a great number of deaths and hospitalizations worldwide. Secondary bacterial infections are a very common cause of IAV associated morbidity and mortality. The robust inflammatory response that follows infection is important for the control of virus proliferation but is also associated with lung damage, morbidity and death. The role of the different components of immune response underlying protection or disease during IAV infection is not completely elucidated. Overall, in the context of IAV infection, inflammation is a 'double edge sword' necessary to control infection but causing disease. Therefore, a growing number of studies suggest that immunomodulatory strategies may improve disease outcome without affecting the ability of the host to deal with infection. This review summarizes recent aspects of the inflammatory responses triggered by IAV that are preferentially involved in causing severe pulmonary disease and the anti-inflammatory strategies that have been suggested to treat influenza induced immunopathology.
KEYWORDS:
Immunopathology; Inflammation; Influenza; Secondary infection
PMID: 27744631 DOI: 10.1007/s00011-016-0996-0
[PubMed - as supplied by publisher]