Announcement

Collapse
No announcement yet.

Direct IL-6 Signals Maximize Protective Secondary CD4 T Cell Responses against Influenza

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Direct IL-6 Signals Maximize Protective Secondary CD4 T Cell Responses against Influenza

    J Immunol. 2016 Sep 19. pii: 1600033. [Epub ahead of print]
    Direct IL-6 Signals Maximize Protective Secondary CD4 T Cell Responses against Influenza.

    Strutt TM1, McKinstry KK1, Kuang Y2, Finn CM3, Hwang JH3, Dhume K3, Sell S4, Swain SL2.
    Author information

    Abstract

    Memory T cells can often respond against pathogens that have evaded neutralizing Abs and are thus key to vaccine-induced protection, yet the signals needed to optimize their responses are unclear. In this study, we identify a dramatic and selective requirement for IL-6 to achieve optimal memory CD4 T cell recall following heterosubtypic influenza A virus (IAV) challenge of mice primed previously with wild-type or attenuated IAV strains. Through analysis of endogenous T cell responses and adoptive transfer of IAV-specific memory T cell populations, we find that without IL-6, CD4+, but not CD8+, secondary effector populations expand less and have blunted function and antiviral impact. Early and direct IL-6 signals to memory CD4 T cells are required to program maximal secondary effector responses at the site of infection during heterosubtypic challenge, indicating a novel role for a costimulatory cytokine in recall responses.
    Copyright ? 2016 by The American Association of Immunologists, Inc.


    PMID: 27647834 DOI: 10.4049/jimmunol.1600033
    [PubMed - as supplied by publisher]
Working...
X