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J Infect Dis. 2016 Sep 21. pii: jiw448. [Epub ahead of print]
Increased Pro-Inflammatory Responses of Monocytes and Plasmacytoid Dendritic Cells to Influenza A Virus Infection During Pregnancy.
Le Gars M1, Kay AW2, Bayless NL3, Aziz N4, Dekker CL2, Swan GE5, Davis MM6, Blish CA1.
Author information
Abstract
Pregnancy-induced alterations in immunity may contribute to the increased morbidity associated with influenza A virus (IAV) infection during pregnancy. We characterized the immune response of monocytes and plasmacytoid dendritic cells (pDCs) to IAV infection in pregnant (n=21) and non-pregnant (n=21) women. In pregnant women, monocytes and pDCs exhibit an exaggerated pro-inflammatory immune response to two strains of IAV compared to non-pregnant women, characterized by increased expression of MHC class II (∼2.0-fold), CD69 (∼2.2-fold), interferon gamma induced protein 10 (IP-10, ∼2.0-fold) and macrophage inflammatory protein-1β (MIP-1β, ∼1.5-fold). This enhanced innate inflammatory response during pregnancy could contribute to pulmonary inflammation following IAV infection.
? The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
PMID: 27655870 DOI: 10.1093/infdis/jiw448
[PubMed - as supplied by publisher]
Increased Pro-Inflammatory Responses of Monocytes and Plasmacytoid Dendritic Cells to Influenza A Virus Infection During Pregnancy.
Le Gars M1, Kay AW2, Bayless NL3, Aziz N4, Dekker CL2, Swan GE5, Davis MM6, Blish CA1.
Author information
Abstract
Pregnancy-induced alterations in immunity may contribute to the increased morbidity associated with influenza A virus (IAV) infection during pregnancy. We characterized the immune response of monocytes and plasmacytoid dendritic cells (pDCs) to IAV infection in pregnant (n=21) and non-pregnant (n=21) women. In pregnant women, monocytes and pDCs exhibit an exaggerated pro-inflammatory immune response to two strains of IAV compared to non-pregnant women, characterized by increased expression of MHC class II (∼2.0-fold), CD69 (∼2.2-fold), interferon gamma induced protein 10 (IP-10, ∼2.0-fold) and macrophage inflammatory protein-1β (MIP-1β, ∼1.5-fold). This enhanced innate inflammatory response during pregnancy could contribute to pulmonary inflammation following IAV infection.
? The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
PMID: 27655870 DOI: 10.1093/infdis/jiw448
[PubMed - as supplied by publisher]