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J Infect Dis. 2016 Aug 4. pii: jiw346. [Epub ahead of print]
Pre-existing ADCC antibody responses are stable longitudinally and cross-reactive responses are not boosted by recent influenza exposure.
Valkenburg SA1, Zhang Y2, Chan KY2, Leung K2, Wu JT2, Poon LL3.
Author information
Abstract
Cross-reactive influenza-specific ADCC antibodies are readily detected in healthy adults. However, little is known about the kinetics of these ADCC responses. We utilized retrospective serial blood samples from healthy donors to investigate this topic. All donors had ADCC responses against the pandemic H1N1 and avian H7N9 HA despite being seronegative for these viruses in standard HAI and MN serological assays. Pandemic H1N1-2009 exposure did not boost ADCC responses specific for H7-HA antigens. H7-HA ADCC responses were variable longitudinally within donors, suggesting these cross-reactive antibodies are unstable. We found no correlation between influenza-specific IgG1, age and ADCC responses to the H7-HA.
? The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
PMID: 27493238 DOI: 10.1093/infdis/jiw346
[PubMed - as supplied by publisher]
Pre-existing ADCC antibody responses are stable longitudinally and cross-reactive responses are not boosted by recent influenza exposure.
Valkenburg SA1, Zhang Y2, Chan KY2, Leung K2, Wu JT2, Poon LL3.
Author information
Abstract
Cross-reactive influenza-specific ADCC antibodies are readily detected in healthy adults. However, little is known about the kinetics of these ADCC responses. We utilized retrospective serial blood samples from healthy donors to investigate this topic. All donors had ADCC responses against the pandemic H1N1 and avian H7N9 HA despite being seronegative for these viruses in standard HAI and MN serological assays. Pandemic H1N1-2009 exposure did not boost ADCC responses specific for H7-HA antigens. H7-HA ADCC responses were variable longitudinally within donors, suggesting these cross-reactive antibodies are unstable. We found no correlation between influenza-specific IgG1, age and ADCC responses to the H7-HA.
? The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
PMID: 27493238 DOI: 10.1093/infdis/jiw346
[PubMed - as supplied by publisher]