Announcement

Collapse
No announcement yet.

Front Immunol . T-cell count and T-cell telomere length in patients with severe COVID-19

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Front Immunol . T-cell count and T-cell telomere length in patients with severe COVID-19

    Front Immunol


    . 2024 Mar 14:15:1356638.
    doi: 10.3389/fimmu.2024.1356638. eCollection 2024. T-cell count and T-cell telomere length in patients with severe COVID-19

    Bryan D Kraft 1 , Simon Verhulst 2 , Tsung-Po Lai 3 , Bruce A Sullenger 4 , Yunfei Wang 5 , Wes Rountree 5 , Lingye Chen 1 , Christopher W Woods 6 7 , Thomas N Denny 5 , Abraham Aviv 3 8



    AffiliationsAbstract

    Lymphocyte telomere length (TL) is highly variable and shortens with age. Short telomeres may impede TL-dependent T-cell clonal expansion with viral infection. As SARS-CoV-2 infection can induce prolonged and severe T-cell lymphopenia, infected adults, and particularly older adults with short telomeres, may display severe T-cell lymphopenia. To examine the relationship between T-cell TL parameters and T-cell counts, we studied 40 patients hospitalized with severe COVID-19. T-cells were isolated from lymphocytes, counted using flow cytometry, and their TL parameters were measured using the Telomere Shortest Length Assay. The cohort (median age = 62 years, 27% female) was racially and ethnically diverse (33% White, 35% Black, and 33% Other). On intensive care unit study day 1, T-cell count (mean=1.03 x109/L) was inversely related to age (p=0.007) and higher in females than males (p=0.025). Mean TL was 3.88 kilobases (kb), and 45.3% of telomeres were shorter than 3 kb. Using multiple regression analysis and adjusting for age and sex, T-cell count decreased with increased proportion of T-cell telomeres shorter than 3 kb (p=0.033) and increased with mean TL (p=0.052). Our findings suggest an association between the buildup of short telomeres within T-cells and explain in part reduced peripheral blood T-cell counts in patients with severe COVID-19. Shortened T-cell telomeres may be a risk factor for COVID-19-associated T-cell lymphopenia.

    Keywords: COVID-19; SARS-CoV-2; T-lymphocytes; aging; lymphopenia; sex; telomere.

    ‚Äč
Working...
X