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Clin Transl Med . Elevated ubiquitination contributes to protective immunity against severe SARS-CoV-2 infection

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  • Clin Transl Med . Elevated ubiquitination contributes to protective immunity against severe SARS-CoV-2 infection


    Clin Transl Med


    . 2022 Dec;12(12):e1103.
    doi: 10.1002/ctm2.1103.
    Elevated ubiquitination contributes to protective immunity against severe SARS-CoV-2 infection


    Yinggang Che 1 2 , Dongbo Jiang 1 3 , Yong Zhang 2 , Junqi Zhang 1 , Tianqi Xu 2 , Yuanjie Sun 1 , Jiangjiang Fan 4 , Jiawei Wang 1 , Ning Chang 2 , Yingtong Wu 5 , Shuya Yang 1 , Leidi Xu 2 , Jiaqi Ding 1 , Chenchen Hu 1 , Yinan Huang 1 , Jian Zhang 2 , Kun Yang 1 3 6



    Affiliations

    Abstract

    Background: The crosstalk between the ubiquitin-proteasome and the immune system plays an important role in the health and pathogenesis of viral infection. However, there have been few studies of ubiquitin activation in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
    Methods: We investigated the effect of ubiquitination on SARS-CoV-2 infection and patient prognosis by integrating published coronavirus disease 2019 (COVID-19) multi-transcriptome data and bioinformatics methods.
    Results: The differential expression of COVID-19 samples revealed changed ubiquitination in most solid and hollow organs, and it was activated in lymphatic and other immune tissues. In addition, in the respiratory system of COVID-19 patients, the immune response was mainly focused on the alveoli, and the expression of ubiquitination reflected increasing immune infiltration. Ubiquitination stratification could significantly differentiate patients' prognosis and inflammation levels through the general transcriptional analysis of the peripheral blood of patients with COVID-19. Moreover, high ubiquitination levels were associated with a favourable prognosis, low inflammatory response, and reduced mechanical ventilation and intensive care unit. Moreover, high ubiquitination promoted a beneficial immune response while inhibiting immune damage. Finally, prognostic stratification and biomarker screening based on ubiquitination traits played an important role in clinical management and drug development.
    Conclusion: Ubiquitination characteristics provides new ideas for clinical intervention and prognostic guidance for COVID-19 patients.

    Keywords: biomarker; immune system; prognosis; severe acute respiratory syndrome coronavirus 2; ubiquitination.

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