Immunol Rev
. 2022 Nov 28.
doi: 10.1111/imr.13175. Online ahead of print.
Neutrophils during SARS-CoV-2 infection: Friend or foe?
Fernanda V S Castanheira 1 2 3 , Paul Kubes 1 2 3
Affiliations
- PMID: 36440642
- DOI: 10.1111/imr.13175
Abstract
Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in more than 6 million deaths worldwide. COVID-19 is a respiratory disease characterized by pulmonary dysfunction leading to acute respiratory distress syndrome (ARDs), as well as disseminated coagulation, and multi-organ dysfunction. Neutrophils and neutrophil extracellular traps (NETs) have been implicated in the pathogenesis of COVID-19. In this review, we highlight key gaps in knowledge, discuss the heterogeneity of neutrophils during the evolution of the disease, how they can contribute to COVID-19 pathogenesis, and potential therapeutic strategies that target neutrophil-mediated inflammatory responses.
Keywords: COVID-19; SARS-CoV-2; neutrophil extracellular traps; neutrophil heterogeneity; neutrophils; sepsis.