Immunol Rev . Neutrophils during SARS-CoV-2 infection: Friend or foe?

[tetano]

Immunol Rev


. 2022 Nov 28.
doi: 10.1111/imr.13175. Online ahead of print.
Neutrophils during SARS-CoV-2 infection: Friend or foe?


Fernanda V S Castanheira ^{1 2 3} , Paul Kubes ^{1 2 3}



Affiliations

• PMID: 36440642
• DOI: 10.1111/imr.13175

Abstract

Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in more than 6 million deaths worldwide. COVID-19 is a respiratory disease characterized by pulmonary dysfunction leading to acute respiratory distress syndrome (ARDs), as well as disseminated coagulation, and multi-organ dysfunction. Neutrophils and neutrophil extracellular traps (NETs) have been implicated in the pathogenesis of COVID-19. In this review, we highlight key gaps in knowledge, discuss the heterogeneity of neutrophils during the evolution of the disease, how they can contribute to COVID-19 pathogenesis, and potential therapeutic strategies that target neutrophil-mediated inflammatory responses.

Keywords: COVID-19; SARS-CoV-2; neutrophil extracellular traps; neutrophil heterogeneity; neutrophils; sepsis.