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FEBS Open Bio . Transcriptional dynamics of granulocytes in direct response to incubation with SARS-CoV-2

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  • FEBS Open Bio . Transcriptional dynamics of granulocytes in direct response to incubation with SARS-CoV-2


    FEBS Open Bio


    . 2022 Oct 22.
    doi: 10.1002/2211-5463.13500. Online ahead of print.
    Transcriptional dynamics of granulocytes in direct response to incubation with SARS-CoV-2


    Daigo Nakazawa # 1 , Yohei Takeda # 2 3 , Masatoshi Kanda # 4 , Utano Tomaru 5 , Haruko Ogawa 3 , Takashi Kudo 1 , Satoka Shiratori-Aso 1 , Kanako Watanabe-Kusunoki 1 , Yusho Ueda 1 , Atsuko Miyoshi 1 , Fumihiko Hattanda 1 , Saori Nishio 1 , Ryo Uozumi 6 , Akihiro Ishizu 7 , Tatsuya Atsumi 1



    AffiliationsFree article

    Abstract

    Severe coronavirus disease 2019 (COVID-19) is characterized by acute respiratory distress syndrome and multiple organ dysfunction, in which the host immune response plays a pivotal role. Excessive neutrophil activation and subsequent superfluity of neutrophil extracellular traps (NETs) can lead to tissue damage, and several studies have shown the involvement of neutrophils in severe COVID-19. However, the detailed responses of each neutrophil subset to SARS-CoV-2 infection has not been fully described. To explore this issue, we incubated normal-density granulocytes (NDGs) and low-density granulocytes (LDGs) with different viral titers of SARS-CoV-2. NDGs form NETs with chromatin fibers in response to SARS-CoV-2, whereas LDGs incubated with SARS-CoV-2 display a distinct morphology with condensed nuclei and moderate transcriptional changes. Based on these transcriptional changes, we suggest that AGO2 possibly plays a role in LDG regulation in response to SARS-CoV-2.

    Keywords: SARS-CoV-2; granulocytes; low density granulocytes; neutrophil extracellular traps; severe COVID-19.

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