Announcement

Collapse
No announcement yet.

Open Forum Infect Dis . Persistence of Robust Humoral Immune Response in Coronavirus Disease 2019 Convalescent Individuals Over 12 Months After Infection

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Open Forum Infect Dis . Persistence of Robust Humoral Immune Response in Coronavirus Disease 2019 Convalescent Individuals Over 12 Months After Infection


    Open Forum Infect Dis


    . 2021 Dec 10;9(2):ofab626.
    doi: 10.1093/ofid/ofab626. eCollection 2022 Feb.
    Persistence of Robust Humoral Immune Response in Coronavirus Disease 2019 Convalescent Individuals Over 12 Months After Infection


    Kei Miyakawa 1 , Sousuke Kubo 1 2 , Sundararaj Stanleyraj Jeremiah 1 , Hirofumi Go 3 , Yutaro Yamaoka 1 4 , Norihisa Ohtake 5 6 , Hideaki Kato 7 , Satoshi Ikeda 8 , Takahiro Mihara 9 , Ikuro Matsuba 10 , Naoko Sanno 11 , Masaaki Miyakawa 12 13 , Masaharu Shinkai 14 , Tomoyuki Miyazaki 15 , Takashi Ogura 8 , Shuichi Ito 16 , Takeshi Kaneko 2 , Kouji Yamamoto 3 , Atsushi Goto 9 , Akihide Ryo 1



    Affiliations

    Abstract

    Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection elicits varying degrees of protective immunity conferred by neutralizing antibodies (nAbs). In this study, we report the persistence of nAb responses over 12 months after infection despite their decreasing trend noticed from 6 months.
    Methods: The study included sera from 497 individuals who had been infected with SARS-CoV-2 between January and August 2020. Samples were collected at 6 and 12 months after onset. The titers of immunoglobulin (Ig)G to the viral nucleocapsid protein (NP) and receptor-binding domain (RBD) of the spike protein were measured by chemiluminescence enzyme immunoassay. The nAb titer was determined using lentivirus-based pseudovirus or authentic virus.
    Results: Antibody titers of NP-IgG, RBD-IgG, and nAbs were higher in severe and moderate cases than in mild cases at 12 months after onset. Although the nAb levels were likely to confer adequate protection against wild-type viral infection, the neutralization activity to recently circulating variants in some of the mild cases (~30%) was undermined, implying the susceptibility to reinfection with the variants of concerns (VOCs).
    Conclusions: Coronavirus disease 2019 convalescent individuals have robust humoral immunity even at 12 months after infection albeit that the medical history and background of patients could affect the function and dynamics of antibody response to the VOCs.

    Keywords: SARS-CoV-2; humoral immunity; neutralizing antibodies.

Working...
X