Eur J Clin Microbiol Infect Dis . Clinical and immunological characteristics in COVID-19 convalescent patients

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Eur J Clin Microbiol Infect Dis


. 2021 Oct 9.
doi: 10.1007/s10096-021-04360-w. Online ahead of print.
Clinical and immunological characteristics in COVID-19 convalescent patients


Zhiying Su ^{# 1} , Wenjia Hu ^{# 1} , Qianyun Liu ^{# 2} , Yongxi Zhang ¹ , Tielong Chen ¹ , Yingying Zhou ¹ , Zhen Zhang ² , Yu Chen ^{# 2} , Rongrong Yang ^{# 1} , Yong Xiong ^{# 3} , Xinghuan Wang ^{# 4}



Affiliations

• PMID: 34625887
• DOI: 10.1007/s10096-021-04360-w

Abstract

The humoral and cellular immunity of convalescent COVID-19 patients is involved in pathogenesis and vaccine immunity. In this study, through CoV-psV neutralization assay and IFN-γ ELISpot testing in 30 cases of COVID-19 patients after 9 months post-SARS-CoV-2 infection, it found that the ratio of memory/naive CD4⁺ T lymphocytes cells and levels of anti-SARS-CoV-2-IgM and RBD-IgM were slightly but significantly higher in COVID-19 severe convalescent patients than that in non-severe patients. The specific cellular and humoral immunity against SARS-CoV-2 were detectable, regardless of the severity of the disease in the acute phase. This information may help understanding the immune status after SARS-CoV-2 infection.

Keywords: Humoral immunity; Neutralizing antibodies; SARS-CoV-2; Virus-specific T cells.