Open Forum Infect Dis . The Association of Human Leukocyte Antigen and COVID-19 in Southern China

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Open Forum Infect Dis


. 2021 Aug 6;8(9):ofab410.
doi: 10.1093/ofid/ofab410. eCollection 2021 Sep.
The Association of Human Leukocyte Antigen and COVID-19 in Southern China


Xueping Yu ¹ , Kuoting Ho ^{2 3} , Zhongliang Shen ⁴ , Xiaoying Fu ² , Hongbo Huang ⁵ , Delun Wu ² , Yancheng Lin ² , Yijian Lin ⁵ , Wenhuang Chen ¹ , Milong Su ⁶ , Chao Qiu ⁴ , Xibin Zhuang ⁵ , Zhijun Su ¹



Affiliations

• PMID: 34552996
• PMCID: PMC8436377
• DOI: 10.1093/ofid/ofab410

Abstract

Human leukocyte antigen (HLA) polymorphism is hypothesized to be associated with diverse immune responses toward infectious diseases. Herein, by comparing against multiple subpopulation groups as control, we confirmed that HLA-B*15:27 and HLA-DRB1*04:06 were associated with coronavirus disease 2019 susceptibility in China. Both alleles were predicted to have weak binding affinities toward viral proteins.

Keywords: COVID-19; HLA; SARS-CoV-2; population stratification; susceptibility.