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Life (Basel) . Previous Humoral Immunity to the Endemic Seasonal Alphacoronaviruses NL63 and 229E Is Associated with Worse Clinical Outcome in COVID-19 and Suggests Original Antigenic Sin

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  • Life (Basel) . Previous Humoral Immunity to the Endemic Seasonal Alphacoronaviruses NL63 and 229E Is Associated with Worse Clinical Outcome in COVID-19 and Suggests Original Antigenic Sin


    Life (Basel)


    . 2021 Apr 1;11(4):298.
    doi: 10.3390/life11040298.
    Previous Humoral Immunity to the Endemic Seasonal Alphacoronaviruses NL63 and 229E Is Associated with Worse Clinical Outcome in COVID-19 and Suggests Original Antigenic Sin


    Daniele Focosi 1 , Angelo Genoni 2 , Ersilia Lucenteforte 3 , Silvia Tillati 3 , Antonio Tamborini 4 , Pietro Giorgio Spezia 5 , Lorenzo Azzi 2 6 , Andreina Baj 2 4 , Fabrizio Maggi 2 4



    Affiliations

    Abstract

    Antibody-dependent enhancement (ADE) of severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) infection has been hypothesized. However, to date, there has been no in vitro or in vivo evidence supporting this. Cross-reactivity exists between SARS CoV-2 and other Coronaviridae for both cellular and humoral immunity. We show here that IgG against nucleocapsid protein of alphacoronavirus NL63 and 229E correlate with the World Health Organization's (WHO) clinical severity score ? 5 (incidence rate ratios was 1.87 and 1.80, respectively, and 1.94 for the combination). These laboratory findings suggest possible ADE of SARS CoV-2 infection by previous alphacoronavirus immunity.

    Keywords: 229E; COVID-19; HKU1; NL63; OC43; SARS-CoV-2; convalescent plasma; neutralizing antibody.


  • #2
    Other recent papers that provide further perspectives on this issue include:-

    1. Two Different Antibody-Dependent Enhancement (ADE) Risks for SARS-CoV-2 Antibodies
    https://www.frontiersin.org/articles...21.640093/full

    2. Neutralizing antibodies against SARS-CoV-2: current understanding, challenge and perspective

    https://academic.oup.com/abt/article/3/4/285/6053820

    3. Antibody-Dependent Enhancement and the Critical Pattern of COVID-19: Possibilities and Considerations
    https://www.karger.com/Article/Abstract/516693

    4. SARS-CoV-2 neutralizing antibody levels are correlated with severity of COVID-19 pneumonia
    https://www.sciencedirect.com/scienc...222?via%3Dihub

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