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Available online 15 June 2020
Highlights
•Human BCG vaccination induces a persistent innate immune training of CD14+ monocytes
•BCG vaccination imprints a persistent transcriptomic myeloid bias on human HSPCs
•Hepatic nuclear factors are regulators of BCG-induced trained immunity in HSPCs
•BCG induces persistent epigenetic changes in peripheral CD14+ monocytes
https://www.cell.com/cell-host-micro...128(20)30296-1
The results are also interesting when looking at the Covid-19 pandemic: several studies are currently testing the application of the vaccine to prevent serious disease course in risk groups such as hospital staff and the elderly.
Highlights
•Human BCG vaccination induces a persistent innate immune training of CD14+ monocytes
•BCG vaccination imprints a persistent transcriptomic myeloid bias on human HSPCs
•Hepatic nuclear factors are regulators of BCG-induced trained immunity in HSPCs
•BCG induces persistent epigenetic changes in peripheral CD14+ monocytes
https://www.cell.com/cell-host-micro...128(20)30296-1
The results are also interesting when looking at the Covid-19 pandemic: several studies are currently testing the application of the vaccine to prevent serious disease course in risk groups such as hospital staff and the elderly.