Transpl Infect Dis
. 2020 Jun 5;e13349.
doi: 10.1111/tid.13349. Online ahead of print.
Failed Antibody Response in a Renal Transplant Recipient With SARS-CoV-2 Infected
Zhiping Xia 1 , Xiaojun Liu 2 , Xiaoyan Hu 1 , Zibiao Zhong 1 , Yanfeng Wang 1 , Guizhu Peng 1 , Qifa Ye 1
Affiliations
- PMID: 32500922
- DOI: 10.1111/tid.13349
Abstract
In late December 2019, severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) has been identified as a novel pathogen causing Coronavirus Disease 2019 (COVID-19) in Wuhan, China, subsequently spread to the rest of China and has been demonstrating a rapid global spread. Nucleic acid testing (NAT, tested by real-time polymerase chain reaction) of SARS-CoV-2 virus in oropharyngeal/nasal swab samples has been described to be extremely sensitive for the diagnose of SARS-CoV-2 infection, but false-negative results have been reported. Recent months, researches demonstrated the importance of IgM/IgG antibody detecting due to the unsatisfied positive rate of NAT, and the increasement IgM/IgG antibody was considered as a confirmed criteria of diagnosis in the official guides of the diagnosis and treatment of COVID-19 in China (7th Edition) .
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