J Infect Dis Decreased B Cells on Admission Was Associated With Prolonged Viral RNA Shedding From Respiratory Tract in Coronavirus Disease 2019: A Case Control Study

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J Infect Dis


. 2020 May 31;jiaa311.
doi: 10.1093/infdis/jiaa311. Online ahead of print.
Decreased B Cells on Admission Was Associated With Prolonged Viral RNA Shedding From Respiratory Tract in Coronavirus Disease 2019: A Case Control Study


Shaorui Hao ¹ , Jiangshan Lian ¹ , Yingfeng Lu ¹ , Hongyu Jia ¹ , Jianhua Hu ¹ , Guodong Yu ¹ , Xiaoyan Wang ¹ , Kaijin Xu ¹ , Qin Ni ¹ , Yongtao Li ¹ , Jun Liu ¹ , Hong Zhao ¹ , Xuan Zhang ¹ , Liang Yu ¹ , Xiaopeng Yu ¹ , Dairong Xiang ¹ , Yu Chen ² , Shufa Zheng ² , Yunqing Qiu ¹ , Lanjuan Li ¹ , Tingbo Liang ³ , Yida Yang ¹ , Jifang Sheng ¹



Affiliations

• PMID: 32474608
• DOI: 10.1093/infdis/jiaa311

Abstract

The viral RNA shedding time of SARS-CoV-2 has not been well characterized. Clinical data were collected and compared between patients with short and long viral RNA shedding (in the first and last quarter). The probability of recurrent positive RT-PCR results decreased sharply to 4.8% after three consecutive negatives. At least three consecutive negatives were suitable for the criteria of end of viral RNA shedding. The viral RNA shedding from respiratory tract in patients with normal B cell count was significantly shorter than patients with decreased B cell on admission (median [IQR], 11[9-13] vs 16[12-20] days, P=0.001).

Keywords: B cells; COVID-19; IL-10; T cells; viral RNA shedding.



? The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.