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Nat Med. Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

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  • Nat Med. Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19


    Nat Med. 2020 May 12. doi: 10.1038/s41591-020-0901-9. [Epub ahead of print]
    Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.


    Liao M1, Liu Y1, Yuan J2, Wen Y1, Xu G1, Zhao J1, Cheng L1, Li J2, Wang X1, Wang F2, Liu L3,4, Amit I5, Zhang S6, Zhang Z7,8.

    Author information




    Abstract

    Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.



    PMID:32398875DOI:10.1038/s41591-020-0901-9


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