Nat Med. 2020 May 12. doi: 10.1038/s41591-020-0901-9. [Epub ahead of print]
Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.
Liao M1, Liu Y1, Yuan J2, Wen Y1, Xu G1, Zhao J1, Cheng L1, Li J2, Wang X1, Wang F2, Liu L3,4, Amit I5, Zhang S6, Zhang Z7,8.
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Abstract
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.
PMID:32398875DOI:10.1038/s41591-020-0901-9