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J Virol. 2015 Sep 16. pii: JVI.01292-15. [Epub ahead of print]
Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus.
Van Poucke S1, Doedt J2, Baumann J2, Qiu Y1, Matrosovich T2, Klenk HD2, Van Reeth K3, Matrosovich M4.
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Abstract
Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differed from putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for avian-to-mammalian adaptation. We found that introduction of avian-virus-like amino acids at five other HA positions (62, 81, 92, 144 and 193) of A/Hong Kong/1/1968 virus decreased viral replication in human cells and transmission in pigs. Thus, substitutions at some of these positions facilitated emergence of the pandemic virus.
Copyright ? 2015, American Society for Microbiology. All Rights Reserved.
PMID: 26378170 [PubMed - as supplied by publisher]
Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus.
Van Poucke S1, Doedt J2, Baumann J2, Qiu Y1, Matrosovich T2, Klenk HD2, Van Reeth K3, Matrosovich M4.
Author information
Abstract
Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differed from putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for avian-to-mammalian adaptation. We found that introduction of avian-virus-like amino acids at five other HA positions (62, 81, 92, 144 and 193) of A/Hong Kong/1/1968 virus decreased viral replication in human cells and transmission in pigs. Thus, substitutions at some of these positions facilitated emergence of the pandemic virus.
Copyright ? 2015, American Society for Microbiology. All Rights Reserved.
PMID: 26378170 [PubMed - as supplied by publisher]