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Vaccines (Basel) . Intranasal Treatment of Ferrets with Inert Bacterial Spores Reduces Disease Caused by a Challenging H7N9 Avian Influenza Virus

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  • Vaccines (Basel) . Intranasal Treatment of Ferrets with Inert Bacterial Spores Reduces Disease Caused by a Challenging H7N9 Avian Influenza Virus


    Vaccines (Basel)


    . 2022 Sep 19;10(9):1559.
    doi: 10.3390/vaccines10091559.
    Intranasal Treatment of Ferrets with Inert Bacterial Spores Reduces Disease Caused by a Challenging H7N9 Avian Influenza Virus


    Joe James 1 , Stephanie M Meyer 1 , Huynh A Hong 2 , Chau Dang 2 , Ho T Y Linh 3 , William Ferreira 2 , Paidamoyo M Katsande 4 , Linh Vo 2 , Daniel Hynes 5 , William Love 5 , Ashley C Banyard 1 , Simon M Cutting 2 4



    Affiliations

    Abstract

    Background: Influenza is a respiratory infection that continues to present a major threat to human health, with ~500,000 deaths/year. Continued circulation of epidemic subtypes in humans and animals potentially increases the risk of future pandemics. Vaccination has failed to halt the evolution of this virus and next-generation prophylactic approaches are under development. Naked, "heat inactivated", or inert bacterial spores have been shown to protect against influenza in murine models. Methods: Ferrets were administered intranasal doses of inert bacterial spores (DSM 32444K) every 7 days for 4 weeks. Seven days after the last dose, the animals were challenged with avian H7N9 influenza A virus. Clinical signs of infection and viral shedding were monitored. Results: Clinical symptoms of infection were significantly reduced in animals dosed with DSM 32444K. The temporal kinetics of viral shedding was reduced but not prevented. Conclusion: Taken together, nasal dosing using heat-stable spores could provide a useful approach for influenza prophylaxis in both humans and animals.

    Keywords: Bacillus subtilis; bacterial spores; influenza; innate immunity; prophylaxis.

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