J Infect . Detection of PB2 627K mutation in two highly pathogenic isolates of the H7N9 subtype influenza A virus from chickens in northern China

[tetano]

J Infect


. 2020 Aug 20;S0163-4453(20)30558-2.
doi: 10.1016/j.jinf.2020.08.024. Online ahead of print.
Detection of PB2 627K mutation in two highly pathogenic isolates of the H7N9 subtype influenza A virus from chickens in northern China


Jinyuan Gu ¹ , Min Gu ¹ , Yayao Yan ¹ , Kaituo Liu ¹ , Xiaoquan Wang ¹ , Xiulong Xu ² , Xiufan Liu ³



Affiliations

• PMID: 32828821
• DOI: 10.1016/j.jinf.2020.08.024

Free article

Abstract

PB2 E627K mutation of influenza A virus has been considered relevant to increased mammalian virulence and adaptation. In H7N9, the substitution is naturally confined to most human isolates and few low pathogenic avian isolates. However, we isolated two highly pathogenic H7N9 variants harboring PB2 627K from chickens in northern China.

Keywords: H7N9; Highly pathogenic; PB2 627K.