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Influenza Other Respir Viruses. 2020 Mar 10. doi: 10.1111/irv.12736. [Epub ahead of print] Seroprevalence of H7N9 infection among humans: A systematic review and meta-analysis.
Wang Q1,2, Xu K3, Xie W1,2, Yang L1,2, Chen H4, Shi N1,2, Bao C3, Huang H3, Zhang X3, Liao Y5, Jin H1,2.
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Abstract
In spring 2013, a novel avian-origin influenza A (H7N9) virus emerged in mainland China. The burden of H7N9 infection was estimated based on systematic review and meta-analysis. The systematic search for available literature was conducted using Chinese and English databases. We calculated the pooled seroprevalence of H7N9 infection and its 95% confidence interval by using Freeman-Tukey double arcsine transformation. Out of 16 890 records found using Chinese and English databases, 54 articles were included in the meta-analysis. These included studies of a total of 64 107 individuals. The pooled seroprevalence of H7N9 infection among humans was 0.122% (95% CI: 0.023, 0.275). In high-risk populations, the highest pooled seroprevalence was observed among close contacts (1.075%, 95% CI: 0.000, 4.357). The seroprevalence among general population was (0.077%, 95% CI: 0.011, 0.180). Our study discovered that asymptomatic infection of H7N9 virus did occur, even if the seroprevalence among humans was low.
? 2020 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.
KEYWORDS:
H7N9; influenza A; meta-analysis; seroprevalence; systematic review
PMID: 32157809 DOI: 10.1111/irv.12736
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