Persistence of H7N9 virus antibody response 2 years after infection

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Influenza Other Respir Viruses. 2019 Dec 19. doi: 10.1111/irv.12702. [Epub ahead of print] Persistence of H7N9 virus antibody response 2 years after infection.

Yao L¹, Wang GL¹, Chen LL², Liu C², Duan LJ¹, Gray GC^3,4,5, Ma MJ¹.
Author information

1 State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China. 2 Suzhou Municipal Center for Disease Control and Prevention, Suzhou, China. 3 Division of Infectious Diseases, School of Medicine, Global Health Institute, Duke University, Durham, North Carolina. 4 Global Health Research Center, Duke-Kunshan University, Kunshan, China. 5 Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore City, Singapore.

Abstract

We measured antibodies against H7N9 virus 2 years after infection in 14 patients who were infected during October 2016-September 2017. Approximately 2 years after infection, antibody titers ≥10 were detectable in 13 (92.9%) patients. Three (21.4%) of 14 patients had hemagglutination inhibition titers ≥40, and their geometric mean titer (GMT) was 20 (95% CI 15.7-28.1), whereas 10 (71.4%) and all 14 (100%) of the 14 patients had titers ≥40, and GMTs at 34.4 (95% CI 25.7-51.2) and 73.45 (54.7-106.7) for neuraminidase inhibition and microneutralization antibodies, respectively. Our findings suggest that H7N9 infection may induce long-term antibody response at least 2 years after infection.
? 2019 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.


KEYWORDS:

H7N9 viruses; antibody response; influenza A virus; persistence; serological

PMID: 31856341 DOI: 10.1111/irv.12702
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