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The PB2 and M genes of genotype S H9N2 virus contribute to the enhanced fitness of H5Nx and H7N9 avian influenza viruses in chickens

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  • The PB2 and M genes of genotype S H9N2 virus contribute to the enhanced fitness of H5Nx and H7N9 avian influenza viruses in chickens

    Virology. 2019 Jul 8;535:218-226. doi: 10.1016/j.virol.2019.07.001. [Epub ahead of print]
    The PB2 and M genes of genotype S H9N2 virus contribute to the enhanced fitness of H5Nx and H7N9 avian influenza viruses in chickens.

    Hao X1, Wang X1, Hu J1, Gu M1, Wang J1, Deng Y1, Jiang D1, He D1, Xu H1, Yang Y1, Hu Z1, Chen S1, Hu S1, Liu X1, Shang S1, Peng D1, Jiao X2, Liu X3.
    Author information

    Abstract

    Genotype S H9N2 viruses frequently donate their internal genes to facilitate the generation of novel influenza viruses, e.g., H5N6, H7N9, and H10N8, which have caused human infection. Genotype S was originated from the replacement of F/98-like M and PB2 genes of the genotype H with those from G1-like lineage. However, whether this gene substitution will influence the viral fitness of emerging influenza viruses remains unclear. We found that H5Nx and H7N9 viruses with G1-like PB2 or M gene exhibited higher virulence and replication than those with F/98-like PB2 or M in chickens. We also determined the functional significance of G1-like PB2 in conferring increased polymerase activity and improved nucleus transportation efficiency, and facilitated RNP nuclear export by G1-like M. Our results suggest that G1-like PB2 and M genes optimize viral fitness, and thus play a crucial role in the genesis of emerging influenza viruses that cause rising prevalence in chickens.
    Copyright ? 2019 Elsevier Inc. All rights reserved.


    KEYWORDS:

    Avian influenza virus; Chickens; G1-like PB2 and M; H5Nx; H7N9; Viral fitness

    PMID: 31325836 DOI: 10.1016/j.virol.2019.07.001
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