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Emerg Microbes Infect. 2019;8(1):94-102. doi: 10.1080/22221751.2018.1560234.
Diverse biological characteristics and varied virulence of H7N9 from Wave 5.
Bao L1, Bi Y2,3, Wong G2,4, Qi W5, Li F1, Lv Q1, Wang L3, Liu F3, Yang Y2, Zhang C3, Liu WJ6, Quan C6, Jia W5, Liu Y2, Liu W3, Liao M5, Gao GF2,3,6, Qin C1.
Author information
Abstract
There was a substantial increase with infections of H7N9 avian influenza virus (AIV) in humans during Wave 5 (2016-2017). To investigate whether H7N9 had become more infectious/transmissible and pathogenic overall, we characterized the receptor binding and experimentally infected ferrets with highly pathogenic (HP)- and low pathogenic (LP)-H7N9 isolates selected from Wave 5, and compared their pathogenicity and transmissibility with a Wave 1 isolate from 2013. Studies show that A/Anhui/1/2013 (LP) and A/Chicken/Heyuan/16876/2016 (HP) were highly virulent in ferrets, A/Guangdong/Th008/2017 (HP) and A/Chicken/Huizhou/HZ-3/2017 (HP) had moderate virulence and A/Shenzhen/Th001/2016 (LP) was of low virulence in ferrets. Transmission was observed only in ferrets infected with A/Anhui/1/2013 and A/Chicken/Heyuan/16876/2016, consistent with the idea that sicker ferrets had a higher probability to transmit virus to naive animals. Given the Varied virulence and transmissibility observed in circulating H7N9 viruses from Wave 5, we conclude that the current public health risk of H7N9 has not substantially increased compared to 2013 and the circulating viruses are quite diverse.
KEYWORDS:
H7N9; ferret; influenza; pathogenicity; receptor; transmissibility
PMID: 30866763 DOI: 10.1080/22221751.2018.1560234
Diverse biological characteristics and varied virulence of H7N9 from Wave 5.
Bao L1, Bi Y2,3, Wong G2,4, Qi W5, Li F1, Lv Q1, Wang L3, Liu F3, Yang Y2, Zhang C3, Liu WJ6, Quan C6, Jia W5, Liu Y2, Liu W3, Liao M5, Gao GF2,3,6, Qin C1.
Author information
Abstract
There was a substantial increase with infections of H7N9 avian influenza virus (AIV) in humans during Wave 5 (2016-2017). To investigate whether H7N9 had become more infectious/transmissible and pathogenic overall, we characterized the receptor binding and experimentally infected ferrets with highly pathogenic (HP)- and low pathogenic (LP)-H7N9 isolates selected from Wave 5, and compared their pathogenicity and transmissibility with a Wave 1 isolate from 2013. Studies show that A/Anhui/1/2013 (LP) and A/Chicken/Heyuan/16876/2016 (HP) were highly virulent in ferrets, A/Guangdong/Th008/2017 (HP) and A/Chicken/Huizhou/HZ-3/2017 (HP) had moderate virulence and A/Shenzhen/Th001/2016 (LP) was of low virulence in ferrets. Transmission was observed only in ferrets infected with A/Anhui/1/2013 and A/Chicken/Heyuan/16876/2016, consistent with the idea that sicker ferrets had a higher probability to transmit virus to naive animals. Given the Varied virulence and transmissibility observed in circulating H7N9 viruses from Wave 5, we conclude that the current public health risk of H7N9 has not substantially increased compared to 2013 and the circulating viruses are quite diverse.
KEYWORDS:
H7N9; ferret; influenza; pathogenicity; receptor; transmissibility
PMID: 30866763 DOI: 10.1080/22221751.2018.1560234