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Emerg Infect Dis. 2018 Apr 17;24(4). doi: 10.3201/eid2404.171995. [Epub ahead of print]
Influenza A(H7N9) Virus Antibody Responses in Survivors 1 Year after Infection, China, 2017.
Ma MJ, Liu C, Wu MN, Zhao T, Wang GL, Yang Y, Gu HJ, Cui PW, Pang YY, Tan YY, Hang H, Lin B, Qin JC, Fang LQ, Cao WC, Cheng LL.
Abstract
Avian influenza A(H7N9) virus has caused 5 epidemic waves in China since its emergence in 2013. We investigated the dynamic changes of antibody response to this virus over 1 year postinfection in 25 patients in Suzhou City, Jiangsu Province, China, who had laboratory-confirmed infections during the fifth epidemic wave, Oct 1, 2016-February 14, 2017. Most survivors had relatively robust antibody responses that decreased but remained detectable at 1 year. Antibody response was variable; several survivors had low or undetectable antibody titers. Hemagglutination inhibition titer was >1:40 for <40% of the survivors. Measured in vitro in infected mice, hemagglutination inhibition titer predicted serum protective ability. Our findings provide a helpful serologic guideline for identifying subclinical infections and for developing effective vaccines and therapeutics to counter H7N9 virus infections.
KEYWORDS:
China; H7N9 viruses; antibody response; cohort; influenza; influenza A(H7N9); persistence; serological; survivors; viruses
PMID: 29432091 DOI: 10.3201/eid2404.171995
Influenza A(H7N9) Virus Antibody Responses in Survivors 1 Year after Infection, China, 2017.
Ma MJ, Liu C, Wu MN, Zhao T, Wang GL, Yang Y, Gu HJ, Cui PW, Pang YY, Tan YY, Hang H, Lin B, Qin JC, Fang LQ, Cao WC, Cheng LL.
Abstract
Avian influenza A(H7N9) virus has caused 5 epidemic waves in China since its emergence in 2013. We investigated the dynamic changes of antibody response to this virus over 1 year postinfection in 25 patients in Suzhou City, Jiangsu Province, China, who had laboratory-confirmed infections during the fifth epidemic wave, Oct 1, 2016-February 14, 2017. Most survivors had relatively robust antibody responses that decreased but remained detectable at 1 year. Antibody response was variable; several survivors had low or undetectable antibody titers. Hemagglutination inhibition titer was >1:40 for <40% of the survivors. Measured in vitro in infected mice, hemagglutination inhibition titer predicted serum protective ability. Our findings provide a helpful serologic guideline for identifying subclinical infections and for developing effective vaccines and therapeutics to counter H7N9 virus infections.
KEYWORDS:
China; H7N9 viruses; antibody response; cohort; influenza; influenza A(H7N9); persistence; serological; survivors; viruses
PMID: 29432091 DOI: 10.3201/eid2404.171995