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Sci Immunol. 2017 Jul 14;2(13). pii: eaan2676. doi: 10.1126/sciimmunol.aan2676.
Preferential induction of cross-group influenza A hemagglutinin stem-specific memory B cells after H7N9 immunization in humans.
Andrews SF1, Joyce MG2, Chambers MJ2, Gillespie RA2, Kanekiyo M2, Leung K2, Yang ES2, Tsybovsky Y3, Wheatley AK4, Crank MC2, Boyington JC2, Prabhakaran MS2, Narpala SR2, Chen X2, Bailer RT2, Chen G2, Coates E2, Kwong PD2, Koup RA2, Mascola JR2, Graham BS2, Ledgerwood JE2, McDermott AB1.
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Abstract
Antigenic drift and shift of influenza strains underscore the need for broadly protective influenza vaccines. One strategy is to design immunogens that elicit B cell responses against conserved epitopes on the hemagglutinin (HA) stem. To better understand the elicitation of HA stem-targeted B cells to group 1 and group 2 influenza subtypes, we compared the memory B cell response to group 2 H7N9 and group 1 H5N1 vaccines in humans. Upon H7N9 vaccination, almost half of the HA stem-specific response recognized the group 1 and group 2 subtypes, whereas the response to H5N1 was largely group 1-specific. Immunoglobulin repertoire analysis of HA-specific B cells indicated that the H7N9 and H5N1 vaccines induced genetically similar cross-group HA stem-binding B cells, albeit at a much higher frequency upon H7N9 vaccination. These data suggest that a group 2-based stem immunogen could prove more effective than a group 1 immunogen at eliciting broad cross-group protection in humans.
Copyright ? 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
PMID: 28783708 DOI: 10.1126/sciimmunol.aan2676
Preferential induction of cross-group influenza A hemagglutinin stem-specific memory B cells after H7N9 immunization in humans.
Andrews SF1, Joyce MG2, Chambers MJ2, Gillespie RA2, Kanekiyo M2, Leung K2, Yang ES2, Tsybovsky Y3, Wheatley AK4, Crank MC2, Boyington JC2, Prabhakaran MS2, Narpala SR2, Chen X2, Bailer RT2, Chen G2, Coates E2, Kwong PD2, Koup RA2, Mascola JR2, Graham BS2, Ledgerwood JE2, McDermott AB1.
Author information
Abstract
Antigenic drift and shift of influenza strains underscore the need for broadly protective influenza vaccines. One strategy is to design immunogens that elicit B cell responses against conserved epitopes on the hemagglutinin (HA) stem. To better understand the elicitation of HA stem-targeted B cells to group 1 and group 2 influenza subtypes, we compared the memory B cell response to group 2 H7N9 and group 1 H5N1 vaccines in humans. Upon H7N9 vaccination, almost half of the HA stem-specific response recognized the group 1 and group 2 subtypes, whereas the response to H5N1 was largely group 1-specific. Immunoglobulin repertoire analysis of HA-specific B cells indicated that the H7N9 and H5N1 vaccines induced genetically similar cross-group HA stem-binding B cells, albeit at a much higher frequency upon H7N9 vaccination. These data suggest that a group 2-based stem immunogen could prove more effective than a group 1 immunogen at eliciting broad cross-group protection in humans.
Copyright ? 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
PMID: 28783708 DOI: 10.1126/sciimmunol.aan2676