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Sci Rep. 2017 May 4;7(1):1512. doi: 10.1038/s41598-017-01761-w.
Epidemiological, clinical, and virologic features of two family clusters of avian influenza A (H7N9) virus infections in Southeast China.
Xie J1,2, Weng Y1,2, Ou J1,2, Zhao L1, Zhang Y1, Wang J1, Chen W1, Huang M1, Xiu W1, Chen H1, Zhang Y1, Wu B1, He W1, Zhu Y1, You L1, Huang Z1, Zhang C1, Hong L1,2, Wang W3,4, Zheng K5,6.
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Abstract
This study aimed to investigate the epidemiological, clinical, and virologic characteristics of avian influenza A (H7N9) confirmed cases from two family clusters in Southeast China. Epidemiological data of the H7N9 confirmed cases and their close contacts were obtained through interviews and reviews of medical records. Of the four patients in these two family clusters, two cases had mild symptoms, one had severe symptoms, and one died. Three of the four patients had a history of exposure to live poultry or contaminated environments. The complete genome sequences of the H7N9 viruses from the same family cluster were highly homologous, and the four isolated viruses from the two family clusters exhibited the virologic features of the H7N9 virus, in terms of transmissibility, pathogenicity, host adaptation, and antiviral drug resistance. In addition, our findings indicated that the A/Fujian/18/2015 viral strain contained an additional hemagglutinin G225D substitution, which preferentially binds α2,6-linked sialic acids. The results of this study demonstrate that one family cluster was infected through common exposure to live poultry or contaminated environments, and the other was more likely to be infected through the human-to-human route.
PMID: 28473725 DOI: 10.1038/s41598-017-01761-w
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Epidemiological, clinical, and virologic features of two family clusters of avian influenza A (H7N9) virus infections in Southeast China.
Xie J1,2, Weng Y1,2, Ou J1,2, Zhao L1, Zhang Y1, Wang J1, Chen W1, Huang M1, Xiu W1, Chen H1, Zhang Y1, Wu B1, He W1, Zhu Y1, You L1, Huang Z1, Zhang C1, Hong L1,2, Wang W3,4, Zheng K5,6.
Author information
Abstract
This study aimed to investigate the epidemiological, clinical, and virologic characteristics of avian influenza A (H7N9) confirmed cases from two family clusters in Southeast China. Epidemiological data of the H7N9 confirmed cases and their close contacts were obtained through interviews and reviews of medical records. Of the four patients in these two family clusters, two cases had mild symptoms, one had severe symptoms, and one died. Three of the four patients had a history of exposure to live poultry or contaminated environments. The complete genome sequences of the H7N9 viruses from the same family cluster were highly homologous, and the four isolated viruses from the two family clusters exhibited the virologic features of the H7N9 virus, in terms of transmissibility, pathogenicity, host adaptation, and antiviral drug resistance. In addition, our findings indicated that the A/Fujian/18/2015 viral strain contained an additional hemagglutinin G225D substitution, which preferentially binds α2,6-linked sialic acids. The results of this study demonstrate that one family cluster was infected through common exposure to live poultry or contaminated environments, and the other was more likely to be infected through the human-to-human route.
PMID: 28473725 DOI: 10.1038/s41598-017-01761-w
Free full text