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Cell Immunol. 2016 Apr 9. pii: S0008-8749(16)30020-X. doi: 10.1016/j.cellimm.2016.04.004. [Epub ahead of print]
RIG-I ligand enhances the immunogenicity of recombinant H7HA protein.
Cao W1, Liepkalns JS2, Kamal RP3, Reber AJ2, Kim JH2, Hofstetter AR4, Amoah S3, Stevens J5, Ranjan P2, Gangappa S2, York IA2, Sambhara S2.
Author information
Abstract
Avian H7N9 influenza virus infection with fatal outcomes continues to pose a pandemic threat and highly immunogenic vaccines are urgently needed. In this report we show that baculovirus-derived recombinant H7 hemagglutinin protein, when delivered with RIG-I ligand, induced enhanced antibody and T cell responses and conferred protection against lethal challenge with a homologous H7N9 virus. These findings indicate the potential utility of RIG-I ligands as vaccine adjuvants to increase the immunogenicity of recombinant H7 hemagglutinin.
Published by Elsevier Inc.
KEYWORDS:
Antibody responses; Cell-mediated immunity; H7HA; Influenza; Mouse model; Protective immunity; RIG-I ligand
PMID: 27106062 [PubMed - as supplied by publisher]
RIG-I ligand enhances the immunogenicity of recombinant H7HA protein.
Cao W1, Liepkalns JS2, Kamal RP3, Reber AJ2, Kim JH2, Hofstetter AR4, Amoah S3, Stevens J5, Ranjan P2, Gangappa S2, York IA2, Sambhara S2.
Author information
Abstract
Avian H7N9 influenza virus infection with fatal outcomes continues to pose a pandemic threat and highly immunogenic vaccines are urgently needed. In this report we show that baculovirus-derived recombinant H7 hemagglutinin protein, when delivered with RIG-I ligand, induced enhanced antibody and T cell responses and conferred protection against lethal challenge with a homologous H7N9 virus. These findings indicate the potential utility of RIG-I ligands as vaccine adjuvants to increase the immunogenicity of recombinant H7 hemagglutinin.
Published by Elsevier Inc.
KEYWORDS:
Antibody responses; Cell-mediated immunity; H7HA; Influenza; Mouse model; Protective immunity; RIG-I ligand
PMID: 27106062 [PubMed - as supplied by publisher]