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J Gen Virol. 2014 Oct 1. pii: vir.0.069799-0. doi: 10.1099/vir.0.069799-0. [Epub ahead of print]
Combinations of Oseltamivir and Fibrates Prolong the Mean Survival Time of Mice Infected with the Lethal H7N9 Influenza Virus.
Xu L1, Bao L1, Li F1, Gu S1, Lv Q1, Yuan J1, Xu Y1, Zhu H1, Deng W1, Li Y1, Yao Y1, Yu P1, Gao Z2, Qin C3.
Author information
Abstract
The outbreak of human infections caused by the novel avian-origin H7N9 influenza viruses in China since March 2013 underscores the urgent need to find an effective treatment strategy against H7N9 infection in humans. In this study, we assessed the effectiveness of combinations of oseltamivir and two immunomodulators, simvastatin and fenofibrate, against H7N9 infection in a mouse model. Mice treated with oseltamivir plus fenofibrate exhibited the longest mean survival time, the largest reduction of viral titer in lung tissue, the highest levels of CD4+ and CD8+ T lymphocytes, and the greatest decrease in pulmonary inflammation. Thus, the combination of oseltamivir plus fenofibrate improved the outcomes of mice infected with H7N9 virus by simultaneously reducing viral replication and normalizing the aberrant immune response. This drug combination should be considered in randomized controlled trials of treatments for H7N9 patients.
Copyright ? 2014, the Society for General Microbiology.
KEYWORDS:
H7N9 influenza virus; fenofibrate; mouse model; oseltamivir
PMID:
25274854
[PubMed - as supplied by publisher]
Combinations of Oseltamivir and Fibrates Prolong the Mean Survival Time of Mice Infected with the Lethal H7N9 Influenza Virus.
Xu L1, Bao L1, Li F1, Gu S1, Lv Q1, Yuan J1, Xu Y1, Zhu H1, Deng W1, Li Y1, Yao Y1, Yu P1, Gao Z2, Qin C3.
Author information
Abstract
The outbreak of human infections caused by the novel avian-origin H7N9 influenza viruses in China since March 2013 underscores the urgent need to find an effective treatment strategy against H7N9 infection in humans. In this study, we assessed the effectiveness of combinations of oseltamivir and two immunomodulators, simvastatin and fenofibrate, against H7N9 infection in a mouse model. Mice treated with oseltamivir plus fenofibrate exhibited the longest mean survival time, the largest reduction of viral titer in lung tissue, the highest levels of CD4+ and CD8+ T lymphocytes, and the greatest decrease in pulmonary inflammation. Thus, the combination of oseltamivir plus fenofibrate improved the outcomes of mice infected with H7N9 virus by simultaneously reducing viral replication and normalizing the aberrant immune response. This drug combination should be considered in randomized controlled trials of treatments for H7N9 patients.
Copyright ? 2014, the Society for General Microbiology.
KEYWORDS:
H7N9 influenza virus; fenofibrate; mouse model; oseltamivir
PMID:
25274854
[PubMed - as supplied by publisher]
