No announcement yet.

Proc Natl Acad Sci USA. Topology of viral evolution.

  • Filter
  • Time
  • Show
Clear All
new posts

  • Proc Natl Acad Sci USA. Topology of viral evolution.

    [Source: US National Library of Medicine, full page: (LINK). Abstract, edited.]

    Proc Natl Acad Sci U S A. 2013 Oct 29. [Epub ahead of print]

    Topology of viral evolution.

    Chan JM, Carlsson G, Rabadan R.

    Source: Center for Computational Biology and Bioinformatics and Departments of Biomedical Informatics and Systems Biology, Columbia University College of Physicians and Surgeons, New York, NY 10032.


    The tree structure is currently the accepted paradigm to represent evolutionary relationships between organisms, species or other taxa. However, horizontal, or reticulate, genomic exchanges are pervasive in nature and confound characterization of phylogenetic trees. Drawing from algebraic topology, we present a unique evolutionary framework that comprehensively captures both clonal and reticulate evolution. We show that whereas clonal evolution can be summarized as a tree, reticulate evolution exhibits nontrivial topology of dimension greater than zero. Our method effectively characterizes clonal evolution, reassortment, and recombination in RNA viruses. Beyond detecting reticulate evolution, we succinctly recapitulate the history of complex genetic exchanges involving more than two parental strains, such as the triple reassortment of H7N9 avian influenza and the formation of circulating HIV-1 recombinants. In addition, we identify recurrent, large-scale patterns of reticulate evolution, including frequent PB2-PB1-PA-NP cosegregation during avian influenza reassortment. Finally, we bound the rate of reticulate events (i.e., 20 reassortments per year in avian influenza). Our method provides an evolutionary perspective that not only captures reticulate events precluding phylogeny, but also indicates the evolutionary scales where phylogenetic inference could be accurate.

    KEYWORDS: gene flow, persistent homology, topological data analysis

    PMID: 24170857 [PubMed - as supplied by publisher]


  • #2
    Re: Proc Natl Acad Sci USA. Topology of viral evolution.

    Full paper PDF enclosed.
    Attached Files