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Virus Res. Reassortment ability of the 2009 pandemic H1N1 influenza virus with circulating human and avian influenza viruses: Public Health Risk Implications.

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  • Virus Res. Reassortment ability of the 2009 pandemic H1N1 influenza virus with circulating human and avian influenza viruses: Public Health Risk Implications.

    [Source: US National Library of Medicine, full text: (LINK). Abstract, edited.]
    Virus Res. 2013 Apr 29. pii: S0168-1702(13)00129-9. doi: 10.1016/j.virusres.2013.04.012. [Epub ahead of print]

    Reassortment ability of THE 2009 pandemic H1N1 influenza virus with circulating human and avian influenza viruses: PUBLIC HEALTH RISK IMPLICATIONS.

    Stincarelli M, Arvia R, Marco MA, Clausi V, Corcioli F, Cotti C, Delogu M, Donatelli I, Azzi A, Giannecchini S.

    Source: Virology Unit, Department of Public Health, University of Florence, Florence.


    Abstract

    Exploring the reassortment ability of the 2009 pandemic H1N1 (A/H1N1pdm09) influenza virus with other circulating human or avian influenza viruses is the main concern related to the generation of more virulent or new variants having implications for public health. After different coinfection experiments in human A549 cells, by using the A/H1N1pdm09 virus plus one of human seasonal influenza viruses of H1N1 and H3N2 subtype or one of H11, H10, H9, H7 and H1 avian influenza viruses, several reassortant viruses were obtained. Among these, the HA of H1N1 was the main segment of human seasonal influenza virus reassorted in the A/H1N1pdm09 virus backbone. Conversely, HA and each of the three polymerase segments, alone or in combination, of the avian influenza viruses mainly reassorted in the A/H1N1pdm09 virus backbone. Of note, A/H1N1pdm09 viruses that reassorted with HA of H1N1 seasonal human or H11N6 avian viruses or carried different combination of avian origin polymerase segments, exerted a higher replication effectiveness than that of the parental viruses. These results confirm that reassortment of the A/H1N1pdm09 with circulating low pathogenic avian influenza viruses should not be misjudged in the prediction of the next pandemic.

    Copyright 2013. Published by Elsevier B.V.


    PMID: 23639426 [PubMed - as supplied by publisher]
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  • #2
    Re: Virus Res. Reassortment ability of the 2009 pandemic H1N1 influenza virus with circulating human and avian influenza viruses: Public Health Risk Implications.

    http://www.ncbi.nlm.nih.gov/pubmed/23639426
    well working reassortments in A549 cells are:

    111s1111 (?)
    x11x1111
    1x1x1111
    11xx1111
    xxxx1111

    111s1111
    111e1111
    a1111111,1a111111,11a11111,aa111111,1aa11111,a1a11 111,aaa11111

    1:H1N1pdm,a:avian,e:H11N6,s:old seasonal H1N1,x:{H1N1,H3N2,H11,H10,H9,H7,H1av}

    math symbolism is superior to English grammar
    I'm interested in expert panflu damage estimates
    my current links: [url]http://bit.ly/hFI7H[/url] ILI-charts: [url]http://bit.ly/CcRgT[/url]

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