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Mol Biol Evol . Bidirectional movement of emerging H5N8 avian influenza viruses between Europe and Asia via migratory birds since early 2020

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  • Mol Biol Evol . Bidirectional movement of emerging H5N8 avian influenza viruses between Europe and Asia via migratory birds since early 2020


    Mol Biol Evol


    . 2023 Jan 27;msad019.
    doi: 10.1093/molbev/msad019. Online ahead of print.
    Bidirectional movement of emerging H5N8 avian influenza viruses between Europe and Asia via migratory birds since early 2020


    Guogang Zhang 1 , Bingying Li 2 , Jayna Raghwani 3 4 , Bram Vrancken 5 6 , Ru Jia 1 , Sarah C Hill 4 , Guillaume FourniƩ 4 , Yanchao Cheng 2 , Qiqi Yang 7 , Yuxin Wang 2 , Zengmiao Wang 2 , Lu Dong 8 , Oliver G Pybus 3 4 , Huaiyu Tian 2



    Affiliations

    Abstract

    Migratory birds play a critical role in the rapid spread of highly pathogenic avian influenza (HPAI) H5N8 virus clade 2.3.4.4 across Eurasia. Elucidating the timing and pattern of virus transmission is essential therefore for understanding the spatial dissemination of these viruses. In this study, we surveyed >27000 wild birds in China, tracked the year-round migration patterns of 20 bird species across China since 2006, and generated new HPAI H5N8 virus genomic data. Using this new dataset, we investigated the seasonal transmission dynamics of HPAI H5N8 viruses across Eurasia. We found that introductions of HPAI H5N8 viruses to different Eurasian regions were associated with the seasonal migration of wild birds. Moreover, we report a backflow of HPAI H5N8 virus lineages from Europe to Asia, suggesting that Europe acts as both a source and a sink in the global HPAI virus transmission network.


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