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Encephalitis and Death in Wild Mammals at a Rehabilitation Center after Systemic Infection with Highly Pathogenic Avian Influenza A(H5N8) Virus, United Kingdom in late 2020

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  • Encephalitis and Death in Wild Mammals at a Rehabilitation Center after Systemic Infection with Highly Pathogenic Avian Influenza A(H5N8) Virus, United Kingdom in late 2020

    Source: https://wwwnc.cdc.gov/eid/article/27/11/21-1225_article


    Encephalitis and Death in Wild Mammals at a Rehabilitation Center after Systemic Infection with Highly Pathogenic Avian Influenza A(H5N8) Virus, United Kingdom

    Tobias Floyd, Ashley C. BanyardComments to Author , Fabian Z.X. Lean, Alexander M.P. Byrne, Edward Fullick, Elliot Whittard, Benjamin C. Mollett, Steve Bexton, Vanessa Swinson, Michele Macrelli, Nicola S. Lewis, Scott M. Reid, Alejandro Núñez, J. Paul Duff, Rowena Hansen, and Ian H. Brown
    Author affiliations: Animal and Plant Health Agency, Weybridge, UK (T. Floyd, A.C. Banyard, F.Z.X Lean, A.M.P. Byrne, E. Whittard, B.C. Mollett, S.M. Reid, A. Núñez, R. Hansen, I.H. Brown); Animal and Plant Health Agency, Thirsk, UK (E. Fullick, V. Swinson); Royal Society for Prevention of Cruelty to Animals, East Winch, UK (S. Bexton); Animal and Plant Health Agency, Bury St Edmunds, UK (M. Macrelli); Royal Veterinary College Department of Pathobiology and Population Sciences, North Mymms, UK (N.S. Lewis); Animal and Plant Health Agency Diseases of Wildlife Scheme, Penrith, UK (J.P. Duff)

    Abstract

    We report a disease and mortality event involving swans, seals, and a fox at a wildlife rehabilitation center in the United Kingdom during late 2020. Five swans had onset of highly pathogenic avian influenza virus infection while in captivity. Subsequently, 3 seals and a fox died (or were euthanized) after onset of clinical disease. Avian-origin influenza A virus subtype H5N8 was retrospectively determined as the cause of disease. Infection in the seals manifested as seizures, and immunohistochemical and molecular testing on postmortem samples detected a neurologic distribution of viral products. The fox died overnight after sudden onset of inappetence, and postmortem tissues revealed neurologic and respiratory distribution of viral products. Live virus was isolated from the swans, seals, and the fox, and a single genetic change was detected as a potential adaptive mutation in the mammalian-derived viral sequences. No human influenza-like illness was reported in the weeks after the event...

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