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Transbound Emerg Dis. 2019 Nov 1. doi: 10.1111/tbed.13406. [Epub ahead of print] Domestic ducks play a major role in the maintenance and spread of H5N8 highly pathogenic avian influenza viruses in South Korea.
Kwon JH1, Bahl J2,3, Swayne DE1, Lee YN4, Lee YJ4, Song CS5, Lee DH6.
Author information
1 U.S. National Poultry Research Center, Agricultural Research Service, U.S. Department of Agriculture, Athens, GA, USA. 2 Center for Ecology of Infectious Disease, Dept of Infectious Disease, Dept of Epidemiology and Biostatistics, Institute of Bioinformatics, University of Georgia, Athens, GA. 3 Emerging Infectious Disease, Duke-NUS Graduate Medical School, Singapore. 4 Avian Influenza Research & Diagnostic Division, Animal and Plant Quarantine Agency, Gimcheon-si, Republic of Korea. 5 Avian Diseases Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, South Korea. 6 Department of Pathobiology and Veterinary Science, the University of Connecticut, Storrs, CT, USA.
Abstract
The H5N8 highly pathogenic avian influenza viruses (HPAIV) belonging to clade 2.3.4.4 spread from Eastern China to Korea in 2014 and caused outbreaks in domestic poultry until 2016. To understand how H5N8 HPAIV spread at host species level in Korea during 2014-2016, a Bayesian phylogenetic analysis was used for ancestral state reconstruction and estimation of the host transition dynamics between wild waterfowl, domestic ducks, and chickens. Our data supports that H5N8 HPAIV most likely transmitted from wild waterfowl to domestic ducks, then maintained in domestic ducks followed by dispersal of HPAIV from domestic ducks to chickens, suggesting domestic duck population plays a central role in the maintenance, amplification and spread of wild HPAIV to terrestrial poultry in Korea.
? 2019 Blackwell Verlag GmbH.
KEYWORDS:
Domestic duck; H5N8; Highly pathogenic avian influenza; Phylogenetic; Waterfowl
PMID: 31675474 DOI: 10.1111/tbed.13406