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Highly pathogenic avian influenza H5N8 Clade 2.3.4.4B virus in Uganda, 2017

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  • Highly pathogenic avian influenza H5N8 Clade 2.3.4.4B virus in Uganda, 2017

    Infect Genet Evol. 2018 Oct 17. pii: S1567-1348(18)30508-2. doi: 10.1016/j.meegid.2018.10.010. [Epub ahead of print]
    Highly pathogenic avian influenza H5N8 Clade 2.3.4.4B virus in Uganda, 2017.

    Ndumu D1, Zecchin B2, Fusaro A2, Arinaitwe E1, Erechu R1, Kidega E1, Kayiwa J3, Muwanga E1, Kirumira M1, Kirembe G1, Lutwama J3, Monne I4.
    Author information

    Abstract

    In early January 2017, outbreaks of H5N8 highly pathogenic avian influenza (HPAI) were reported for the first time in wild and domestic birds along the shores and on some islands of Lake Victoria, in central-southern Uganda. Our whole-genome phylogenetic analyses revealed that the H5N8 viruses recovered from the outbreak in Uganda belonged to genetic clade 2.3.4.4 group-B and clustered with viruses collected in 2017 in the Democratic Republic of the Congo and in West Africa. Our results suggested that infected migratory wild birds might have played a crucial role in the introduction of HPAI H5N8 into this region.


    KEYWORDS:

    H5N8 subtype; Influenza A virus; Migratory wild birds; Phylogeny; Uganda

    PMID: 30342095 DOI: 10.1016/j.meegid.2018.10.010
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