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Genetic features of highly pathogenic avian influenza viruses A(H5N8), isolated from the European part of the Russian Federation

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  • Genetic features of highly pathogenic avian influenza viruses A(H5N8), isolated from the European part of the Russian Federation

    Infect Genet Evol. 2018 May 28. pii: S1567-1348(18)30312-5. doi: 10.1016/j.meegid.2018.05.022. [Epub ahead of print]
    Genetic features of highly pathogenic avian influenza viruses A(H5N8), isolated from the European part of the Russian Federation.

    Voronina OL1, Ryzhova NN2, Aksenova EI2, Kunda MS2, Sharapova NE2, Fedyakina IT2, Chvala IA3, Borisevich SV4, Yu Logunov D2, Gintsburg AL2.
    Author information

    Abstract

    Highly pathogenic avian influenza viruses (HPAIV) A(H5N8) of group B (Gochang1-like) have emerged in the Tyva Republic of eastern Russia in May 2016. Since November 2016, HPAIV A(H5N8) has spread throughout the European part of Russia. Thirty-one outbreaks were reported in domestic, wild and zoo birds in 2017. The present study aimed to perform a comparative analysis of new HPAIV A(H5N8) strains. Phylogenetic analysis revealed four genetically distinct subgroups in HPAIV A(H5N8) from the 2016-2017 season. Russian strains consisted of three subgroups with differences between isolates from Tyva, Siberia (Chany Lake), and the European part of Russia. Strains from the European part of Russia showed the beginnings of divergent evolution. Slight differences of the Voronezh strains were suggested by sensitivity to antiviral compounds. Testing for host-specific mutations in sequenced strains revealed the absence of mutations associated with possible increased tropism/virulence in mammalian species, including humans. Only one residue of polymerase basic-1, 13P, is discussed, because the L13P mutation increased complementary RNA synthesis in mammalian cells. We concluded that the evolution of HPAIV A(H5N8) is continuous. Surveillance in Russia revealed new cases of HPAIV A(H5N8) and led to the elaboration of prevention strategies, which should be implemented.


    KEYWORDS:

    Antiviral compound; Genome sequence; Highly pathogenic avian influenza viruses A(H5N8); Mutation; Outbreak; Phylogeny

    PMID: 29852294 DOI: 10.1016/j.meegid.2018.05.022
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